› 7xv9

X-ray diffraction
1.6Å resolution

Crystal structure of the Human TR4 DNA-Binding Domain

Released:
DOI: 10.2210/pdb7xv9/pdb
PDB entry 7xv9 coloured by chain, front view.
PDB entry 7xv9 coloured by chain, side view.
PDB entry 7xv9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of human TR4LBD-JAZF1 and TR4DBD-DNA complexes reveal the molecular basis of transcriptional regulation.
Liu Y, Ma L, Li M, Tian Z, Yang M, Wu X, Wang X, Shang G, Xie M, Chen Y, Liu X, Jiang L, Wu W, Xu C, Xia L, Li G, Dai S, Chen Z
OpenAccess logo Nucleic Acids Res (2023)
PMID: 36651297

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155862 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear receptor subfamily 2 group C member 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 80 amino acids
Theoretical weight: 9.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: P49116 (Residues: 113-189; Coverage: 13%)
Gene names: NR2C2, TAK1, TR4
Sequence domains: Zinc finger, C4 type (two domains)

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P41
Unit cell:
a: 32.229Å b: 32.229Å c: 128.043Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.176 0.18
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

Quick links

Citations

1 mention without citation

Structures of human TR4LBD-JAZF1 and TR4DBD-DNA complexes reveal the molecular basis of transcriptional regulation.
Liu et al. (2023)