› 7xxa

Electron Microscopy
3.09Å resolution

Complex of Echo 18 and FcRn at pH7.4

Released:
DOI: 10.2210/pdb7xxa/pdb
PDB entry 7xxa coloured by chain, front view.
PDB entry 7xxa coloured by chain, side view.
PDB entry 7xxa coloured by chain, top view.
Source organisms:
Primary publication:
Human FcRn Is a Two-in-One Attachment-Uncoating Receptor for Echovirus 18.
Chen X, Qu X, Liu C, Zhang Y, Zhang G, Han P, Duan Y, Li Q, Wang L, Ruan W, Wang P, Wei W, Gao GF, Zhao X, Xie Z
mBio 13 e0116622 (2022)
PMID: 35862785
Related structures: EMD-33499

Function and Biology Details

Reactions catalysed: 
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
Selective cleavage of Tyr-|-Gly bond in picornavirus polyprotein.
NTP + H(2)O = NDP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 300-mer (preferred)
PDBe Complex ID:
PDB-CPX-103244 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
VP1 Chain: A
Molecule details ›
Chain: A
Length: 312 amino acids
Theoretical weight: 35.11 KDa
Source organism: Echovirus E18
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A1D5AKC8 (Residues: 569-880; Coverage: 14%)
Sequence domains: picornavirus capsid protein
IgG receptor FcRn large subunit p51 Chain: E
Molecule details ›
Chain: E
Length: 263 amino acids
Theoretical weight: 29.29 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P55899 (Residues: 28-290; Coverage: 77%)
Gene names: FCGRT, FCRN
Sequence domains:
VP2 Chain: B
Molecule details ›
Chain: B
Length: 260 amino acids
Theoretical weight: 28.81 KDa
Source organism: Echovirus E18
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A1D5AKC8 (Residues: 70-329; Coverage: 12%)
Sequence domains: picornavirus capsid protein
VP3 Chain: C
Molecule details ›
Chain: C
Length: 239 amino acids
Theoretical weight: 26.13 KDa
Source organism: Echovirus E18
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A1D5AKC8 (Residues: 330-568; Coverage: 11%)
Sequence domains: picornavirus capsid protein
VP4 Chain: D
Molecule details ›
Chain: D
Length: 69 amino acids
Theoretical weight: 7.5 KDa
Source organism: Echovirus E18
Expression system: Homo sapiens
UniProt: Sequence domains: Picornavirus coat protein (VP4)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.09Å
Relevant EMDB volumes: EMD-33499
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Investigating the mechanism of Echovirus 30 cell invasion.
Liang et al. (2023)
2 other articles

1 mention without citation

Human FcRn Is a Two-in-One Attachment-Uncoating Receptor for Echovirus 18.
Chen et al. (2022)