› 7xyu

X-ray diffraction
2.7Å resolution

Crystal structure of ZER1 bound to TFLH degron

Released:
DOI: 10.2210/pdb7xyu/pdb
PDB entry 7xyu coloured by chain, front view.
PDB entry 7xyu coloured by chain, side view.
PDB entry 7xyu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
CRL2ZER1/ZYG11B recognizes small N-terminal residues for degradation.
Li Y, Zhao Y, Yan X, Ye C, Weirich S, Zhang B, Wang X, Song L, Jiang C, Jeltsch A, Dong C, Mi W
Nat Commun 13 7636 (2022)
PMID: 36496439

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182311 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein zer-1 homolog Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 251 amino acids
Theoretical weight: 29.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7Z7L7 (Residues: 520-766; Coverage: 32%)
Gene names: C9orf60, ZER1, ZYG, ZYG11BL
Sequence domains: Protein zer-1 homolog-like, C-terminal domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL02U1
Spacegroup: P61
Unit cell:
a: 67.779Å b: 67.779Å c: 418.181Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.251 0.248 0.304
Expression system: Escherichia coli

Quick links

Citations

3 citation in other articles

Recognition of an Ala-rich C-degron by the E3 ligase Pirh2.
Wang et al. (2023)
2 more

1 mention without citation

CRL2ZER1/ZYG11B recognizes small N-terminal residues for degradation.
Li et al. (2022)