› 7xyw

X-ray diffraction
2.5Å resolution

Crystal structure of ZYG11B bound to AFLH degron

Released:
DOI: 10.2210/pdb7xyw/pdb
PDB entry 7xyw coloured by chain, front view.
PDB entry 7xyw coloured by chain, side view.
PDB entry 7xyw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
CRL2ZER1/ZYG11B recognizes small N-terminal residues for degradation.
Li Y, Zhao Y, Yan X, Ye C, Weirich S, Zhang B, Wang X, Song L, Jiang C, Jeltsch A, Dong C, Mi W
OpenAccess logo Nat Commun 13 7636 (2022)
PMID: 36496439

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189890 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein zyg-11 homolog B Chains: A, B
Molecule details ›
Chains: A, B
Length: 250 amino acids
Theoretical weight: 28.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9C0D3 (Residues: 485-728; Coverage: 33%)
Gene names: KIAA1730, ZYG11B
Sequence domains: Protein zer-1 homolog-like, C-terminal domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL02U1
Spacegroup: P212121
Unit cell:
a: 52.88Å b: 97.266Å c: 122.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.226 0.275
Expression system: Escherichia coli

Quick links

Citations

3 citation in other articles

Recognition of an Ala-rich C-degron by the E3 ligase Pirh2.
Wang et al. (2023)
2 more

1 mention without citation

CRL2ZER1/ZYG11B recognizes small N-terminal residues for degradation.
Li et al. (2022)