› 7y1m

Electron Microscopy
3.57Å resolution

Structure of SUR2B in complex with Mg-ATP, Mg-ADP, and repaglinide in the inward-facing conformation

Released:
DOI: 10.2210/pdb7y1m/pdb
PDB entry 7y1m coloured by chain, front view.
PDB entry 7y1m coloured by chain, side view.
PDB entry 7y1m coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
The inhibition mechanism of the SUR2A-containing KATP channel by a regulatory helix.
Ding D, Hou T, Wei M, Wu JX, Chen L
OpenAccess logo Nat Commun 14 3608 (2023)
PMID: 37330603
Related structures: EMD-33566

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179021 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATP-binding cassette sub-family C member 9 Chain: A
Molecule details ›
Chain: A
Length: 1545 amino acids
Theoretical weight: 174.49 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q63563 (Residues: 1-1541; Coverage: 100%)
  • Best match: Q63563-2 (Residues: 1-1545)
Gene names: Abcc9, Sur2
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand MG 2 x MG
Ligand ATP 1 x ATP
Ligand BJX 1 x BJX
Ligand ADP 1 x ADP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.57Å
Relevant EMDB volumes: EMD-33566
Expression system: Homo sapiens

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