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Cryo-EM structure of a class A orphan GPCR

Electron Microscopy
2.77Å resolution
PDB entry 7y3g coloured by chain, front view.
PDB entry 7y3g coloured by chain, side view.
PDB entry 7y3g coloured by chain, top view.
Source organisms:
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 48072.13 Å2
Buried surface area: 12364.95 Å2
Dissociation area: 1,189.89 Å2
Dissociation energy (ΔGdiss): 1.51 kcal/mol
Dissociation entropy (TΔSdiss): 12.55 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-225655

Macromolecules

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Chain: A
Length: 394 amino acids
Theoretical weight: 45.68 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 7y3g, assembly 1, front view.
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 7y3g, assembly 1, side view.
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 7y3g, assembly 1, top view.
139450100150200250300350
 
100200300MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKNTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGAQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQAALKLFDSIWNNKWLRDTSVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
UniProt
P63092
Chains
Secondary structure
Flexibility predictions
Interaction interfaces
Sequence conservation
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Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Chain: B
Length: 340 amino acids
Theoretical weight: 37.42 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 7y3g, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 7y3g, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 7y3g, assembly 1, top view.
134050100150200250300
 
100200300MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
UniProt
P62873
Chains
Domains
Secondary structure
Interaction interfaces
Sequence conservation
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Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Chain: G
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 7y3g, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 7y3g, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 7y3g, assembly 1, top view.
171510152025303540455055606570
 
204060MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREKKFFCAIL
UniProt
P59768
Chains
Secondary structure
Interaction interfaces
Sequence conservation
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Nanobody 35
Chain: N
Length: 157 amino acids
Theoretical weight: 17.06 KDa
Source organism: Lama glama
Expression system: Escherichia coli
Nanobody 35 in PDB entry 7y3g, assembly 1, front view.
Nanobody 35 in PDB entry 7y3g, assembly 1, side view.
Nanobody 35 in PDB entry 7y3g, assembly 1, top view.
115720406080100120140
 
50100150MKYLLPTAAAGLLLLAAQPAMAMQVQLQESGGGLVQPGGSLRLSCAASGFTFSNYKMNWVRQAPGKGLEWVSDISQSGASISYTGSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCARCPAPFTRDCFDVTSTTYAYRGQGTQVTVSSHHHHHH
Chains
Chain D (auth N)
Secondary structure
Interaction interfaces
Sequence conservation
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G-protein coupled receptor 12
Chain: R
Length: 378 amino acids
Theoretical weight: 42.06 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
G-protein coupled receptor 12 in PDB entry 7y3g, assembly 1, front view.
G-protein coupled receptor 12 in PDB entry 7y3g, assembly 1, side view.
G-protein coupled receptor 12 in PDB entry 7y3g, assembly 1, top view.
137850100150200250300350
 
100200300MKTIIALSYIFCLVFAHHHHHHHHHHDYKDDDDKENLYFQSGAPMNEDLKVNLSGLPRDYLDAAAAENISAAVSSRVPAVEPEPELVVNPWDIVLCTSGTLISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYLLQSEATKLVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSVSFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKALCLICCGCIPSSLAQRARSPSDV
UniProt
P47775
Chains
Secondary structure
Interaction interfaces
Sequence conservation
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