› 7y4s

Electron Microscopy
3.5Å resolution

Structure of human MG53 homo-dimer

Released:
DOI: 10.2210/pdb7y4s/pdb
PDB entry 7y4s coloured by chain, front view.
PDB entry 7y4s coloured by chain, side view.
PDB entry 7y4s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structure of human MG53 homodimer.
Niu Y, Chen G, Lv F, Xiao RP, Hu X, Chen L
Biochem J 479 1909-1916 (2022)
PMID: 36053137
Related structures: EMD-33606

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180582 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tripartite motif-containing protein 72 Chains: A, B
Molecule details ›
Chains: A, B
Length: 477 amino acids
Theoretical weight: 52.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli B
UniProt:
  • Canonical: Q6ZMU5 (Residues: 1-477; Coverage: 100%)
Gene names: MG53, TRIM72
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-33606
Expression system: Escherichia coli B

Quick links

Citations

2 citation in other articles

Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane.
Park et al. (2023)
1 more