› 7y5f

X-ray diffraction
1.52Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-108161 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TauD/TfdA-like domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 358 amino acids
Theoretical weight: 39.09 KDa
Source organism: Saccharothrix mutabilis subsp. capreolus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A6YEH4 (Residues: 1-338; Coverage: 100%)
Gene name: cmnC
Sequence domains: Taurine catabolism dioxygenase TauD, TfdA family

Ligands and Environments

3 bound ligands:
Ligand FE 2 x FE
Ligand HRG 2 x HRG
Ligand TLA 2 x TLA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: I222
Unit cell:
a: 93.344Å b: 127.514Å c: 139.034Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.18 0.204
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 citations in other articles

Discovery and characterization of genes conferring natural resistance to the antituberculosis antibiotic capreomycin.
Toh et al. (2023)

1 mention without citation

Crystal structure of the α-ketoglutarate-dependent non-heme iron oxygenase CmnC in capreomycin biosynthesis and its engineering to catalyze hydroxylation of the substrate enantiomer.
Hsiao et al. (2022)