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Crystal structure of human TFEB HLHLZ domain

X-ray diffraction
2Å resolution
PDB entry 7y62 coloured by chain, front view.
PDB entry 7y62 coloured by chain, side view.
PDB entry 7y62 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Transcription factor EB
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Multimeric state: homo dimer
Accessible surface area: 9843.04 Å2
Buried surface area: 3489.02 Å2
Dissociation area: 1,744.51 Å2
Dissociation energy (ΔGdiss): 28.98 kcal/mol
Dissociation entropy (TΔSdiss): 11.42 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148592

Macromolecules

Transcription factor EB
Chains: A, B
Length: 75 amino acids
Theoretical weight: 8.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19484 (Residues: 248-319; Coverage: 15%)
Gene names: BHLHE35, TFEB
Pfam: Helix-loop-helix DNA-binding domain
InterPro:
Transcription factor EB in PDB entry 7y62, assembly 1, front view.
Transcription factor EB in PDB entry 7y62, assembly 1, side view.
Transcription factor EB in PDB entry 7y62, assembly 1, top view.
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