› 7y75

Electron Microscopy
3.1Å resolution

SIT1-ACE2-BA.2 RBD

Released:
DOI: 10.2210/pdb7y75/pdb
PDB entry 7y75 coloured by chain, front view.
PDB entry 7y75 coloured by chain, side view.
PDB entry 7y75 coloured by chain, top view.
Source organisms:
Primary publication:
Structures of ACE2-SIT1 recognized by Omicron variants of SARS-CoV-2.
Shen Y, Wang J, Li Y, Zhang Y, Tian R, Yan R
OpenAccess logo Cell Discov 8 123 (2022)
PMID: 36384914
Related structures: EMD-33652

Function and Biology Details

Reaction catalysed: 
Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-144625 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Sodium- and chloride-dependent transporter XTRP3 Chains: B, D
Molecule details ›
Chains: B, D
Length: 613 amino acids
Theoretical weight: 68.22 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NP91 (Residues: 1-592; Coverage: 100%)
Gene names: SIT1, SLC6A20, XT3, XTRP3
Sequence domains: Sodium:neurotransmitter symporter family
Angiotensin-converting enzyme 2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 826 amino acids
Theoretical weight: 95.38 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BYF1 (Residues: 2-17, 18-805; Coverage: 100%)
Gene names: ACE2, UNQ868/PRO1885
Sequence domains:
Spike protein S1 Chains: E, F
Molecule details ›
Chains: E, F
Length: 252 amino acids
Theoretical weight: 28.53 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 319-541; Coverage: 18%)
Gene names: 2, S
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand NAG 6 x NAG
Ligand 3PH 6 x 3PH
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-33652
Expression system: Homo sapiens

Quick links

Citations

2 review citations

The Functions of SARS-CoV-2 Receptors in Diabetes-Related Severe COVID-19.
Drzymała A. (2024)
1 more

2 mentions without citation

Structural insight into the substrate recognition and transport mechanism of amino acid transporter complex ACE2-B0AT1 and ACE2-SIT1.
Li et al. (2023)
1 more