› 7ycq

X-ray diffraction
1.99Å resolution

Crystal structure of human transthyretin variant A97S complexed with Diflunisal

Released:
DOI: 10.2210/pdb7ycq/pdb
PDB entry 7ycq coloured by chain, front view.
PDB entry 7ycq coloured by chain, side view.
PDB entry 7ycq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A molecular basis for tetramer destabilization and aggregation of transthyretin Ala97Ser.
Wang YS, Huang CH, Liou GG, Hsueh HW, Liang CT, Tseng HC, Huang SJ, Chao CC, Hsieh ST, Tzeng SR
Protein Sci 32 e4610 (2023)
PMID: 36851846

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 13.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family

Ligands and Environments

1 bound ligand:
Ligand 1FL 2 x 1FL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: P21212
Unit cell:
a: 86.114Å b: 42.228Å c: 64.075Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.182 0.222
Expression system: Escherichia coli

Quick links

Citations

2 citation in other articles

Altered gut microbiota in Taiwanese A97S predominant transthyretin amyloidosis with polyneuropathy.
Chen et al. (2024)
1 more

1 mention without citation

A molecular basis for tetramer destabilization and aggregation of transthyretin Ala97Ser.
Wang et al. (2023)