› 7ydq

Electron Microscopy
4.04Å resolution

Structure of PfNT1(Y190A)-GFP in complex with GSK4

Released:
DOI: 10.2210/pdb7ydq/pdb
PDB entry 7ydq coloured by chain, front view.
PDB entry 7ydq coloured by chain, side view.
PDB entry 7ydq coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1.
Wang C, Yu L, Zhang J, Zhou Y, Sun B, Xiao Q, Zhang M, Liu H, Li J, Li J, Luo Y, Xu J, Lian Z, Lin J, Wang X, Zhang P, Guo L, Ren R, Deng D
OpenAccess logo Nat Commun 14 1727 (2023)
PMID: 36977719
Related structures: EMD-33756

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-214912 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Green fluorescent protein; Nucleoside transporter 1 Chain: A
Molecule details ›
Chain: A
Length: 683 amino acids
Theoretical weight: 77.04 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8IDM6 (Residues: 1-370; Coverage: 88%)
  • Canonical: P42212 (Residues: 2-238; Coverage: 100%)
Gene names: GFP, NT1, PF3D7_1347200
Sequence domains: Green fluorescent protein

Ligands and Environments

1 bound ligand:
Ligand IRX 1 x IRX
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.04Å
Relevant EMDB volumes: EMD-33756
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

Critical interdependencies between Plasmodium nutrient flux and drugs.
Henshall et al. (2023)
3 other articles

1 mention without citation

Enhancing cryo-EM structure prediction with DeepTracer and AlphaFold2 integration.
Chen et al. (2024)