› 7yep

Electron Microscopy
2.83Å resolution

2-APB bound state of mTRPV2

Released:
DOI: 10.2210/pdb7yep/pdb
PDB entry 7yep coloured by chain, front view.
PDB entry 7yep coloured by chain, side view.
PDB entry 7yep coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands.
Su N, Zhen W, Zhang H, Xu L, Jin Y, Chen X, Zhao C, Wang Q, Wang X, Li S, Wen H, Yang W, Guo J, Yang F
Nat Chem Biol 19 72-80 (2023)
PMID: 36163384
Related structures: EMD-33774

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194380 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 756 amino acids
Theoretical weight: 86.06 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9WTR1 (Residues: 1-756; Coverage: 100%)
Gene names: Grc, Trpv2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand FZ4 4 x FZ4
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.83Å
Relevant EMDB volumes: EMD-33774
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Targeting TRP channels: recent advances in structure, ligand binding, and molecular mechanisms.
Huang et al. (2023)
5 other articles

1 mention without citation

Experimental and computational biophysics to identify vasodilator drugs targeted at TRPV2 using agonists based on the probenecid scaffold.
Catalina-Hernández et al. (2024)