› 7yfj

X-ray diffraction
2.4Å resolution

Crystal structure of human WTAP

Released:
DOI: 10.2210/pdb7yfj/pdb
PDB entry 7yfj coloured by chain, front view.
PDB entry 7yfj coloured by chain, side view.
PDB entry 7yfj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
AI-empowered integrative structural characterization of m6A methyltransferase complex.
Yan X, Pei K, Guan Z, Liu F, Yan J, Jin X, Wang Q, Hou M, Tang C, Yin P
OpenAccess logo Cell Res (2022)
PMID: 36357785

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-556588 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pre-mRNA-splicing regulator WTAP Chains: A, B
Molecule details ›
Chains: A, B
Length: 122 amino acids
Theoretical weight: 14.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15007 (Residues: 130-241; Coverage: 28%)
Gene names: KIAA0105, WTAP
Sequence domains: WTAP/Mum2p family

Ligands and Environments

2 bound ligands:
Ligand EDO 1 x EDO
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P6122
Unit cell:
a: 62.754Å b: 62.754Å c: 336.345Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.221 0.22 0.24
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Ghost authors revealed: The structure and function of human N6 -methyladenosine RNA methyltransferases.
Breger et al. (2023)
1 more