7yg5

Electron Microscopy
3Å resolution

Structure of human R-type voltage-gated CaV2.3-alpha2/delta1-beta1 channel complex in the topiramate-bound state

Released:
Source organism: Homo sapiens
Related structures: EMD-33808

Function and Biology Details

Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-156988 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
Voltage-dependent R-type calcium channel subunit alpha-1E Chain: A
Molecule details ›
Chain: A
Length: 2313 amino acids
Theoretical weight: 262.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q15878 (Residues: 1-2313; Coverage: 100%)
Gene names: CACH6, CACNA1E, CACNL1A6
Sequence domains:
Voltage-dependent L-type calcium channel subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 598 amino acids
Theoretical weight: 65.8 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q02641 (Residues: 1-598; Coverage: 100%)
Gene names: CACNB1, CACNLB1
Sequence domains:
Voltage-dependent calcium channel subunit alpha-2/delta-1 Chain: D
Molecule details ›
Chain: D
Length: 1103 amino acids
Theoretical weight: 124.69 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P54289 (Residues: 1-1103; Coverage: 100%)
Gene names: CACNA2D1, CACNL2A, CCHL2A, MHS3
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG, BMA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution:
Relevant EMDB volumes: EMD-33808
Expression system: Homo sapiens