› 7yh4

X-ray diffraction
2.03Å resolution

Crystal structure of human cytosolic beta-alanyl lysine dipeptidase (PM20D2)

Released:
DOI: 10.2210/pdb7yh4/pdb
PDB entry 7yh4 coloured by chain, front view.
PDB entry 7yh4 coloured by chain, side view.
PDB entry 7yh4 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Chandravanshi K, Gaur NK, Kumar A, Makde RD

Function and Biology Details

Reaction catalysed: 
Preferential hydrolysis of Xaa-|-Arg, Xaa-|-Lys or Xaa-|-ornithine dipeptides.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-224532 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Xaa-Arg dipeptidase Chain: A
Molecule details ›
Chain: A
Length: 454 amino acids
Theoretical weight: 49.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8IYS1 (Residues: 20-436; Coverage: 96%)
Gene names: ACY1L2, PM20D2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RRCAT INDUS-2 BEAMLINE PX-BL21
Spacegroup: I222
Unit cell:
a: 78.834Å b: 112.888Å c: 123.217Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.197 0.237
Expression system: Escherichia coli BL21(DE3)

Quick links