› 7ykf

X-ray diffraction
2.28Å resolution

Crystal structure of MAGI2 PDZ0-GK/pEphexin4 complex

Released:
DOI: 10.2210/pdb7ykf/pdb
PDB entry 7ykf coloured by chain, front view.
PDB entry 7ykf coloured by chain, side view.
PDB entry 7ykf coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Phosphorylation-dependent recognition of diverse protein targets by the cryptic GK domain of MAGI MAGUKs.
Zhang M, Cao A, Lin L, Chen Y, Shang Y, Wang C, Zhang M, Zhu J
Sci Adv 9 eadf3295 (2023)
PMID: 37163606

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-236345 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 234 amino acids
Theoretical weight: 25.98 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9WVQ1 (Residues: 9-238; Coverage: 18%)
Gene names: Acvrinp1, Aip1, Arip1, Magi2
Sequence domains:
Rho guanine nucleotide exchange factor 16 Chains: B, D
Molecule details ›
Chains: B, D
Length: 12 amino acids
Theoretical weight: 1.53 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q3U5C8 (Residues: 152-163; Coverage: 2%)
Gene name: Arhgef16

Ligands and Environments

No bound ligands
1 modified residue:
Ligand SEP 2 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P1
Unit cell:
a: 40.209Å b: 55.616Å c: 61.07Å
α: 65.31° β: 76.62° γ: 71.56°
R-values:
R R work R free
0.188 0.186 0.236
Expression system: Escherichia coli BL21(DE3)

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