› 7yl2

X-ray diffraction
1.62Å resolution

Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor Y07004

Released:
DOI: 10.2210/pdb7yl2/pdb
PDB entry 7yl2 coloured by chain, front view.
PDB entry 7yl2 coloured by chain, side view.
PDB entry 7yl2 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Huang Y, Wei A, Dong R, Xu H, Zhang C, Chen Z, Li J, Wu X, Zhang Y, Xu Y

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130112 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 4 Chain: A
Molecule details ›
Chain: A
Length: 141 amino acids
Theoretical weight: 16.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O60885 (Residues: 44-168; Coverage: 9%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain

Ligands and Environments

3 bound ligands:
Ligand JCO 1 x JCO
Ligand GOL 1 x GOL
Ligand NO3 1 x NO3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P212121
Unit cell:
a: 46.18Å b: 50.52Å c: 52.88Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.173 0.204
Expression system: Escherichia coli BL21

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