› 7yl3

Electron Microscopy
3.2Å resolution

Structure of hIAPP-TF-type1

Released:
DOI: 10.2210/pdb7yl3/pdb
PDB entry 7yl3 coloured by chain, front view.
PDB entry 7yl3 coloured by chain, side view.
PDB entry 7yl3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A new polymorphism of human amylin fibrils with similar protofilaments and a conserved core.
Li D, Zhang X, Wang Y, Zhang H, Song K, Bao K, Zhu P
OpenAccess logo iScience 25 105705 (2022)
PMID: 36567711
Related structures: EMD-33902

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145617 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Islet amyloid polypeptide Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 37 amino acids
Theoretical weight: 3.91 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10997 (Residues: 34-70; Coverage: 55%)
Gene name: IAPP
Sequence domains: Calcitonin / CGRP / IAPP family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-33902
Expression system: Not provided

Quick links

Citations

1 citations in other articles

Copper binding and protein aggregation: a journey from the brain to the human lens.
Posadas et al. (2023)