› 7yni

Electron Microscopy
3.26Å resolution

Structure of human SGLT1-MAP17 complex bound with substrate 4D4FDG in the occluded conformation

Released:
DOI: 10.2210/pdb7yni/pdb
PDB entry 7yni coloured by chain, front view.
PDB entry 7yni coloured by chain, side view.
PDB entry 7yni coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of human SGLT in the occluded state reveal conformational changes during sugar transport.
Cui W, Niu Y, Sun Z, Liu R, Chen L
OpenAccess logo Nat Commun 14 2920 (2023)
PMID: 37217492
Related structures: EMD-33962

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146804 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Sodium/glucose cotransporter 1 Chain: A
Molecule details ›
Chain: A
Length: 664 amino acids
Theoretical weight: 73.56 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P13866 (Residues: 1-664; Coverage: 100%)
Gene names: NAGT, SGLT1, SLC5A1
Sequence domains: Sodium:solute symporter family
PDZK1-interacting protein 1 Chain: B
Molecule details ›
Chain: B
Length: 114 amino acids
Theoretical weight: 12.24 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13113 (Residues: 1-114; Coverage: 100%)
Gene names: MAP17, PDZK1IP1
Sequence domains: Membrane-associated protein 117 kDa, PDZK1-interacting protein 1

Ligands and Environments

1 bound ligand:
Ligand KQC 1 x KQC
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.26Å
Relevant EMDB volumes: EMD-33962
Expression system: Homo sapiens

Quick links

Citations

2 citation in other articles

Membrane potential accelerates sugar uptake by stabilizing the outward facing conformation of the Na/glucose symporter vSGLT.
Khan et al. (2023)
1 more