› 7ynk

Electron Microscopy
3.48Å resolution

Structure of human SGLT2-MAP17 complex in the apo state in the inward-facing conformation

Released:
DOI: 10.2210/pdb7ynk/pdb
PDB entry 7ynk coloured by chain, front view.
PDB entry 7ynk coloured by chain, side view.
PDB entry 7ynk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of human SGLT in the occluded state reveal conformational changes during sugar transport.
Cui W, Niu Y, Sun Z, Liu R, Chen L
OpenAccess logo Nat Commun 14 2920 (2023)
PMID: 37217492
Related structures: EMD-33964

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152041 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Sodium/glucose cotransporter 2 Chain: A
Molecule details ›
Chain: A
Length: 672 amino acids
Theoretical weight: 72.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P31639 (Residues: 1-672; Coverage: 100%)
Gene names: SGLT2, SLC5A2
Sequence domains: Sodium:solute symporter family
PDZK1-interacting protein 1 Chain: B
Molecule details ›
Chain: B
Length: 114 amino acids
Theoretical weight: 12.24 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13113 (Residues: 1-114; Coverage: 100%)
Gene names: MAP17, PDZK1IP1
Sequence domains: Membrane-associated protein 117 kDa, PDZK1-interacting protein 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.48Å
Relevant EMDB volumes: EMD-33964
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Risks and Benefits of SGLT-2 Inhibitors for Type 1 Diabetes Patients Using Automated Insulin Delivery Systems-A Literature Review.
Elian et al. (2024)
4 other articles