› 7yob

X-ray diffraction
2.89Å resolution

Crystal structure of Aldehyde dehydrogenase 1A1 from mouse

Released:
DOI: 10.2210/pdb7yob/pdb
PDB entry 7yob coloured by chain, front view.
PDB entry 7yob coloured by chain, side view.
PDB entry 7yob coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structure of aldehyde dehydrogenase 1A1 from mouse.
Zhang X, Ouyang Z
Biochem Biophys Res Commun 628 141-146 (2022)
PMID: 36084552

Function and Biology Details

Reactions catalysed: 
4-aminobutanal + NAD(+) + H(2)O = 4-aminobutanoate + NADH
Benzaldehyde + NAD(+) + H(2)O = benzoate + NADH
An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH
Retinal + NAD(+) + H(2)O = retinoate + NADH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150246 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aldehyde dehydrogenase 1A1 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 507 amino acids
Theoretical weight: 55.36 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P24549 (Residues: 1-501; Coverage: 100%)
Gene names: Ahd-2, Ahd2, Aldh1, Aldh1a1
Sequence domains: Aldehyde dehydrogenase family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NFPSS BEAMLINE BL18U
Spacegroup: P21
Unit cell:
a: 104.062Å b: 156.484Å c: 129.209Å
α: 90° β: 97.97° γ: 90°
R-values:
R R work R free
0.196 0.195 0.249
Expression system: Escherichia coli

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