Function and Biology Details
Reactions catalysed:
(1a) S-adenosyl-L-methionine + G(5')pppAACA-[mRNA] = S-adenosyl-L-homocysteine + G(5')pppAmACA-[mRNA]
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
(1a) (5')pppAACA-[mRNA] + (protein L)-L-histidine = diphosphate + (protein L)-L-histidyl-(5')phosphonato-AACA-[mRNA] + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- P/V phosphoprotein, paramyxoviral
- Phosphoprotein P soyouz module
- Mononegavirales RNA-directed RNA polymerase catalytic domain
- Mononegavirus L protein 2-O-ribose methyltransferase
- RNA-directed RNA polymerase L, C-terminal
- Mononegavirales mRNA-capping domain V
- RNA-directed RNA polymerase, paramyxovirus
Structure analysis Details
Assembly composition:
hetero pentamer (preferred)
Assembly name:
RNA-directed RNA polymerase L and Phosphoprotein (preferred)
PDBe Complex ID:
PDB-CPX-102694 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Phosphoprotein
Molecule details ›
Chains: B, C, D, E
Length: 399 amino acids
Theoretical weight: 41.74 KDa
Source organism: avian paramyxovirus 1
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 399 amino acids
Theoretical weight: 41.74 KDa
Source organism: avian paramyxovirus 1
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
A0A0S2UXI9 (Residues: 1-399; Coverage: 100%)
Sequence domains:
RNA-directed RNA polymerase L
Molecule details ›
Chain: A
Length: 2211 amino acids
Theoretical weight: 249.18 KDa
Source organism: avian paramyxovirus 1
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 2211 amino acids
Theoretical weight: 249.18 KDa
Source organism: avian paramyxovirus 1
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: A0A0S2UX53 (Residues: 1-2204; Coverage: 100%)
Sequence domains:
