› 7yp1

Electron Microscopy
3.54Å resolution

Cryo-EM structure of EBV gHgL-gp42 in complex with mAb 10E4 (localized refinement)

Released:
DOI: 10.2210/pdb7yp1/pdb
PDB entry 7yp1 coloured by chain, front view.
PDB entry 7yp1 coloured by chain, side view.
PDB entry 7yp1 coloured by chain, top view.
Source organisms:
Primary publication:
Non-overlapping epitopes on the gHgL-gp42 complex for the rational design of a triple-antibody cocktail against EBV infection.
Hong J, Zhong L, Liu L, Wu Q, Zhang W, Chen K, Wei D, Sun H, Zhou X, Zhang X, Kang YF, Huang Y, Chen J, Wang G, Zhou Y, Chen Y, Feng QS, Yu H, Li S, Zeng MS, Zeng YX, Xu M, Zheng Q, Chen Y, Zhang X, Xia N
OpenAccess logo Cell Rep Med 4 101296 (2023)
PMID: 37992686
Related structures: EMD-33992

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-243717 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Envelope glycoprotein H Chain: A
Molecule details ›
Chain: A
Length: 201 amino acids
Theoretical weight: 22.77 KDa
Source organism: human gammaherpesvirus 4
Expression system: Homo sapiens
UniProt:
  • Canonical: P03231 (Residues: 20-255; Coverage: 29%)
Gene names: BXLF2, gH
Sequence domains: Herpesvirus glycoprotein H main domain
Envelope glycoprotein L Chain: B
Molecule details ›
Chain: B
Length: 80 amino acids
Theoretical weight: 8.62 KDa
Source organism: human gammaherpesvirus 4
Expression system: Homo sapiens
UniProt:
  • Canonical: P03212 (Residues: 40-127; Coverage: 70%)
Gene names: BKRF2, gL
Sequence domains: Viral glycoprotein L
10E4 heavy chain Chain: D
Molecule details ›
Chain: D
Length: 115 amino acids
Theoretical weight: 12.27 KDa
Source organism: Oryctolagus cuniculus
Expression system: Homo sapiens
10E4 light chain Chain: G
Molecule details ›
Chain: G
Length: 113 amino acids
Theoretical weight: 11.92 KDa
Source organism: Oryctolagus cuniculus
Expression system: Homo sapiens

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.54Å
Relevant EMDB volumes: EMD-33992
Expression system: Homo sapiens

Quick links