› 7yp2

Electron Microscopy
3.52Å resolution

Cryo-EM structure of EBV gHgL-gp42 in complex with mAb 6H2 (localized refinement)

Released:
DOI: 10.2210/pdb7yp2/pdb
PDB entry 7yp2 coloured by chain, front view.
PDB entry 7yp2 coloured by chain, side view.
PDB entry 7yp2 coloured by chain, top view.
Source organisms:
Primary publication:
Non-overlapping epitopes on the gHgL-gp42 complex for the rational design of a triple-antibody cocktail against EBV infection.
Hong J, Zhong L, Liu L, Wu Q, Zhang W, Chen K, Wei D, Sun H, Zhou X, Zhang X, Kang YF, Huang Y, Chen J, Wang G, Zhou Y, Chen Y, Feng QS, Yu H, Li S, Zeng MS, Zeng YX, Xu M, Zheng Q, Chen Y, Zhang X, Xia N
Cell Rep Med 4 101296 (2023)
PMID: 37992686
Related structures: EMD-33994

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-243718 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Envelope glycoprotein H Chain: A
Molecule details ›
Chain: A
Length: 314 amino acids
Theoretical weight: 34.79 KDa
Source organism: human gammaherpesvirus 4
Expression system: Homo sapiens
UniProt:
  • Canonical: P03231 (Residues: 361-674; Coverage: 46%)
Gene names: BXLF2, gH
Sequence domains:
6H2 heavy chain Chain: H
Molecule details ›
Chain: H
Length: 120 amino acids
Theoretical weight: 13.22 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
6H2 light chain Chain: L
Molecule details ›
Chain: L
Length: 112 amino acids
Theoretical weight: 12.31 KDa
Source organism: Mus musculus
Expression system: Homo sapiens

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.52Å
Relevant EMDB volumes: EMD-33994
Expression system: Homo sapiens

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