› 7ypi

Electron Microscopy
3.8Å resolution

Spiral hexamer of the substrate-free Lon protease with a Y224S mutation

Released:
DOI: 10.2210/pdb7ypi/pdb
PDB entry 7ypi coloured by chain, front view.
PDB entry 7ypi coloured by chain, side view.
PDB entry 7ypi coloured by chain, top view.
Source organism: Meiothermus taiwanensis
Primary publication:
A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Li S, Hsieh KY, Kuo CI, Lin TC, Lee SH, Chen YR, Wang CH, Ho MR, Ting SY, Zhang K, Chang CI
Nat Commun 14 7340 (2023)
PMID: 37957149
Related structures: EMD-34001

Function and Biology Details

Reaction catalysed: 
Hydrolysis of proteins in presence of ATP.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-100268 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lon protease Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 793 amino acids
Theoretical weight: 88.48 KDa
Source organism: Meiothermus taiwanensis
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A059VAZ3 (Residues: 1-793; Coverage: 100%)
Gene names: Mcate_02015, lon, lon1_1, lonA1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand AGS 2 x AGS
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-34001
Expression system: Escherichia coli

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