› 7yrx

Solution NMR

Solution structures of a disulfide-directed multicyclic peptide with affinity for HER3

Released:
DOI: 10.2210/pdb7yrx/pdb
PDB entry 7yrx coloured by chain, ensemble of 15 models, front view.
PDB entry 7yrx coloured by chain, ensemble of 15 models, side view.
PDB entry 7yrx coloured by chain, ensemble of 15 models, top view.
Source organism: synthetic construct
Primary publication:
Disulfide-Directed Multicyclic Peptide Libraries for the Discovery of Peptide Ligands and Drugs.
Lu S, Fan S, Xiao S, Li J, Zhang S, Wu Y, Kong C, Zhuang J, Liu H, Zhao Y, Wu C
J Am Chem Soc 145 1964-1972 (2023)
PMID: 36633218

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-225883 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
LH3 Chain: A
Molecule details ›
Chain: A
Length: 31 amino acids
Theoretical weight: 3.44 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 73%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

2 review citations

Biocompatible strategies for peptide macrocyclisation.
He et al. (2024)
1 more