7ytd

Electron Microscopy
3.71Å resolution

Cryo-EM structure of four human FcmR bound to IgM-Fc/J

Released:
Source organism: Homo sapiens
Primary publication:
Immunoglobulin M perception by FcμR.
Nature 615 907-912 (2023)
PMID: 36949194
Related structures: EMD-34086

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentadecamer (preferred)
PDBe Complex ID:
PDB-CPX-215119 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Immunoglobulin heavy constant mu Chains: A, B, C, D, E, F, G, H, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, K, L
Length: 231 amino acids
Theoretical weight: 25.45 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01871 (Residues: 222-433; Coverage: 45%)
  • Best match: P01871-1 (Residues: 222-452)
Gene name: IGHM
Sequence domains: Immunoglobulin C1-set domain
Immunoglobulin J chain Chain: J
Molecule details ›
Chain: J
Length: 136 amino acids
Theoretical weight: 15.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01591 (Residues: 24-159; Coverage: 99%)
Gene names: IGCJ, IGJ, JCHAIN
Sequence domains: Immunoglobulin J chain
Immunoglobulin mu Fc receptor Chains: R, S, U, V
Molecule details ›
Chains: R, S, U, V
Length: 107 amino acids
Theoretical weight: 11.72 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O60667 (Residues: 18-124; Coverage: 29%)
Gene names: FAIM3, FCMR, TOSO
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.71Å
Relevant EMDB volumes: EMD-34086
Expression systems:
  • Homo sapiens
  • Trichoplusia ni