› 7yu4

Electron Microscopy
3.7Å resolution

Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, focused on receptor

Released:
DOI: 10.2210/pdb7yu4/pdb
PDB entry 7yu4 coloured by chain, front view.
PDB entry 7yu4 coloured by chain, side view.
PDB entry 7yu4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the active Gi-coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist.
Akasaka H, Tanaka T, Sano FK, Matsuzaki Y, Shihoya W, Nureki O
OpenAccess logo Nat Commun 13 5417 (2022)
PMID: 36109516
Related structures: EMD-34098

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187714 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lysophosphatidic acid receptor 1 Chain: A
Molecule details ›
Chain: A
Length: 379 amino acids
Theoretical weight: 42.94 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q92633 (Residues: 2-364; Coverage: 100%)
Gene names: EDG2, LPA1, LPAR1
Sequence domains: 7 transmembrane receptor (rhodopsin family)

Ligands and Environments

1 bound ligand:
Ligand K6L 1 x K6L
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.7Å
Relevant EMDB volumes: EMD-34098
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

Detecting and measuring of GPCR signaling - comparison of human induced pluripotent stem cells and immortal cell lines.
Chen et al. (2023)
10 other articles

3 mentions without citation

Structure of the active Gi-coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist.
Akasaka et al. (2022)
2 more