› 7yuy

Electron Microscopy
3.5Å resolution

Structure of a mutated membrane-bound glycosyltransferase

Released:
DOI: 10.2210/pdb7yuy/pdb
PDB entry 7yuy coloured by chain, front view.
PDB entry 7yuy coloured by chain, side view.
PDB entry 7yuy coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Structural and mechanistic insights into fungal β-1,3-glucan synthase FKS1.
Hu X, Yang P, Chai C, Liu J, Sun H, Wu Y, Zhang M, Zhang M, Liu X, Yu H
OpenAccess logo Nature 1-9 (2023)
PMID: 36949198
Related structures: EMD-34115

Function and Biology Details

Reaction catalysed: 
UDP-glucose + ((1->3)-beta-D-glucosyl)(n) = UDP + ((1->3)-beta-D-glucosyl)(n+1)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153686 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
1,3-beta-glucan synthase component FKS1 Chain: F
Molecule details ›
Chain: F
Length: 1876 amino acids
Theoretical weight: 215.09 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P38631 (Residues: 1-1876; Coverage: 100%)
Gene names: CND1, CWH53, ETG1, FKS1, GLS1, GSC1, L8300.6, PBR1, YLR342W
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: BGC
Carbohydrate polymer
6 bound ligands:
Ligand DD9 7 x DD9
Ligand D10 6 x D10
Ligand C14 1 x C14
Ligand HP6 7 x HP6
Ligand D12 3 x D12
Ligand XKP 1 x XKP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-34115
Expression system: Saccharomyces cerevisiae

Quick links

Citations

1 review citation

Lipid-Centric Approaches in Combating Infectious Diseases: Antibacterials, Antifungals and Antivirals with Lipid-Associated Mechanisms of Action.
Ostroumova et al. (2023)
8 other articles