› 7yv1

X-ray diffraction
1.45Å resolution

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-235010 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
GTPase KRas Chain: A
Molecule details ›
Chain: A
Length: 179 amino acids
Theoretical weight: 20.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01116 (Residues: 2-174; Coverage: 91%)
  • Best match: P01116-2 (Residues: 2-174)
Gene names: KRAS, KRAS2, RASK2
Sequence domains: Ras family
KA30L Fab H-chain Chain: H
Molecule details ›
Chain: H
Length: 225 amino acids
Theoretical weight: 24.12 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
KA30L Fab L-chain Chain: L
LUNA18 Chain: I

Ligands and Environments

2 bound ligands:
Ligand GDP 1 x GDP
Ligand MG 1 x MG
6 modified residues:
Ligand MLE 1 x MLE
Ligand MAA 1 x MAA
Ligand 7VU 1 x 7VU
Ligand SAR 1 x SAR
Ligand 7W2 1 x 7W2
Ligand 7VN 1 x 7VN

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SPRING-8 BEAMLINE BL45XU
Spacegroup: P212121
Unit cell:
a: 65.617Å b: 90.373Å c: 116.81Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.24 0.238 0.277
Expression systems:
  • Escherichia coli
  • Homo sapiens
  • Not provided

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