7ywx

Electron Microscopy
12Å resolution

Structure of the human CCAN CENP-A alpha-satellite complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero 27-mer (preferred)
PDBe Complex ID:
PDB-CPX-269923 (preferred)
Entry contents:
20 distinct polypeptide molecules
2 distinct DNA molecules
Macromolecules (22 distinct):
Centromere protein H Chain: H
Molecule details ›
Chain: H
Length: 247 amino acids
Theoretical weight: 28.52 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9H3R5 (Residues: 1-247; Coverage: 100%)
Gene names: CENPH, ICEN35
Sequence domains: Centromere protein H (CENP-H)
Centromere protein I Chain: I
Molecule details ›
Chain: I
Length: 756 amino acids
Theoretical weight: 86.82 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q92674 (Residues: 1-756; Coverage: 100%)
Gene names: CENPI, FSHPRH1, ICEN19, LRPR1
Sequence domains: Mis6
Centromere protein K Chain: K
Centromere protein L Chain: L
Centromere protein M Chain: M
Centromere protein N Chain: N
Centromere protein O Chain: O
Centromere protein Q Chain: Q
Centromere protein U Chain: U
Centromere protein P Chain: P
Centromere protein R Chain: R
Centromere protein T Chain: T
Centromere protein W Chain: W
Centromere protein S Chain: S
Centromere protein X Chain: X
Histone H3-like centromeric protein A Chains: A, E
Histone H4 Chains: B, F
Histone H2A type 1-C Chains: C, G
Histone H2B type 1-C/E/F/G/I Chains: D, V
Centromere protein C Chains: a, b
DNA (171-MER) Chain: i
DNA (171-MER) Chain: J

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 12Å
Relevant EMDB volumes: EMD-14351
Expression systems:
  • Trichoplusia ni
  • Escherichia coli