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Crystal structure of Mycobacterium abscessus Phosphopantetheine adenylyltransferase in complex with Fragment 14

Source organism: Mycobacteroides abscessus
Biochemical function: nucleotidyltransferase activity
Biological process: coenzyme A biosynthetic process
Cellular component: cytoplasm

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EC 2.7.7.3: Pantetheine-phosphate adenylyltransferase

Reaction catalysed:
ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA
Systematic name:
ATP:pantetheine-4'-phosphate adenylyltransferase
Alternative Name(s):
  • 3'-dephospho-CoA pyrophosphorylase
  • Dephospho-CoA diphosphorylase
  • Dephospho-CoA pyrophosphorylase
  • Dephospho-coenzyme A pyrophosphorylase
  • PPAT
  • Pantetheine phosphate adenylyltransferase
  • Phosphopantetheine adenylyltransferase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01467
Domain description: Cytidylyltransferase-like
Occurring in:
  1. Phosphopantetheine adenylyltransferase
The deposited structure of PDB entry 7yya contains 3 copies of Pfam domain PF01467 (Cytidylyltransferase-like) in Phosphopantetheine adenylyltransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001980
Domain description: Phosphopantetheine adenylyltransferase
Occurring in:
  1. Phosphopantetheine adenylyltransferase
IPR004821
Domain description: Cytidyltransferase-like domain
Occurring in:
  1. Phosphopantetheine adenylyltransferase
IPR014729
Domain description: Rossmann-like alpha/beta/alpha sandwich fold
Occurring in:
  1. Phosphopantetheine adenylyltransferase

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