› 7z0q

X-ray diffraction
2.1Å resolution

MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange

Released:
DOI: 10.2210/pdb7z0q/pdb
Model geometry
Fit model/data
PDB entry 7z0q coloured by chain, front view.
PDB entry 7z0q coloured by chain, side view.
PDB entry 7z0q coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange.
Abualrous ET, Stolzenberg S, Sticht J, Wieczorek M, Roske Y, Günther M, Dähn S, Boesen BB, Calvo MM, Biese C, Kuppler F, Medina-García Á, Álvaro-Benito M, Höfer T, Noé F, Freund C
OpenAccess logo Nat Chem Biol (2023)
PMID: 37142807

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-270207 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class II histocompatibility antigen, DR alpha chain Chain: C
Molecule details ›
Chain: C
Length: 192 amino acids
Theoretical weight: 22.21 KDa
Source organism: Homo sapiens
Expression system: Baculovirus expression vector pFastBac1-HM
UniProt:
  • Canonical: P01903 (Residues: 26-217; Coverage: 84%)
Gene names: HLA-DRA, HLA-DRA1
Sequence domains:
Ig-like domain-containing protein Chain: D
Molecule details ›
Chain: D
Length: 198 amino acids
Theoretical weight: 22.97 KDa
Source organism: Homo sapiens
Expression system: Baculovirus expression vector pFastBac1-HM
UniProt:
  • Canonical: D7RIG5 (Residues: 31-228; Coverage: 84%)
Gene name: HLA-DRB1
Sequence domains:
Class-II-associated invariant chain peptide Chain: G

Ligands and Environments

1 bound ligand:
Ligand EDO 9 x EDO
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: R3
Unit cell:
a: 134.094Å b: 134.094Å c: 72.178Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.216 0.215 0.243
Expression system: Baculovirus expression vector pFastBac1-HM

Quick links

Citations

1 review citation

HLA Genes: A Hallmark of Functional Genetic Variation and Complex Evolution.
Lenz TL. (2024)
2 other articles

1 mention without citation

MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange.
Abualrous et al. (2023)