› 7z1t

Electron Microscopy
2.26Å resolution

Connexin43 gap junction channel structure in digitonin

Released:
DOI: 10.2210/pdb7z1t/pdb
PDB entry 7z1t coloured by chain, front view.
PDB entry 7z1t coloured by chain, side view.
PDB entry 7z1t coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the connexin-43 gap junction channel in a putative closed state.
Qi C, Acosta Gutierrez S, Lavriha P, Othman A, Lopez-Pigozzi D, Bayraktar E, Schuster D, Picotti P, Zamboni N, Bortolozzi M, Gervasio FL, Korkhov VM
OpenAccess logo Elife 12 (2023)
PMID: 37535063
Related structures: EMD-14452

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148031 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gap junction alpha-1 protein Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 382 amino acids
Theoretical weight: 43.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P17302 (Residues: 1-382; Coverage: 100%)
Gene names: GJA1, GJAL
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.26Å
Relevant EMDB volumes: EMD-14452
Expression system: Homo sapiens

Quick links

Citations

5 review citations

The Similar and Distinct Roles of Satellite Glial Cells and Spinal Astrocytes in Neuropathic Pain.
McGinnis et al. (2023)
4 more