› 7z1y

X-ray diffraction
1.75Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175096 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein mono-ADP-ribosyltransferase PARP15 Chains: A, B
Molecule details ›
Chains: A, B
Length: 221 amino acids
Theoretical weight: 25.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q460N3 (Residues: 481-678; Coverage: 29%)
Gene names: BAL3, PARP15
Sequence domains: Poly(ADP-ribose) polymerase catalytic domain

Ligands and Environments

2 bound ligands:
Ligand I5F 1 x I5F
Ligand DMS 1 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-1
Spacegroup: P212121
Unit cell:
a: 45.23Å b: 68.33Å c: 158.65Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.226 0.263
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Privileged Scaffolds for Potent and Specific Inhibitors of Mono-ADP-Ribosylating PARPs.
Nizi et al. (2023)

1 mention without citation

[1,2,4]Triazolo[3,4-b]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes.
Murthy et al. (2023)