› 7z27

X-ray diffraction
1.45Å resolution

Crystal structure of the SPOC domain of human RBM15

Released:
DOI: 10.2210/pdb7z27/pdb
Model geometry
Fit model/data
PDB entry 7z27 coloured by chain, front view.
PDB entry 7z27 coloured by chain, side view.
PDB entry 7z27 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The SPOC domain is a phosphoserine binding module that bridges transcription machinery with co- and post-transcriptional regulators.
Appel LM, Franke V, Benedum J, Grishkovskaya I, Strobl X, Polyansky A, Ammann G, Platzer S, Neudolt A, Wunder A, Walch L, Kaiser S, Zagrovic B, Djinovic-Carugo K, Akalin A, Slade D
OpenAccess logo Nat Commun 14 166 (2023)
PMID: 36631525

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-275283 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RNA-binding protein 15 Chains: A, B
Molecule details ›
Chains: A, B
Length: 189 amino acids
Theoretical weight: 20.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96T37 (Residues: 775-960; Coverage: 19%)
Gene names: OTT, OTT1, RBM15
Sequence domains: SPOC domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 45.031Å b: 65.98Å c: 116.808Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.197 0.218
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Interconnections between m<sup>6</sup>A RNA modification, RNA structure, and protein-RNA complex assembly.
Höfler et al. (2024)
2 more

3 mentions without citation

SPOC domain proteins in health and disease.
Appel et al. (2023)
2 more