Function and Biology

Crystal structure of the peptidase domain of collagenase G from Clostridium histolyticum in complex with a hydroxamate-based inhibitor

Source organism: Hathewaya histolytica
Biochemical function: zinc ion binding
Biological process: proteolysis
Cellular component: extracellular region

EC 3.4.24.3: Microbial collagenase

Reaction catalysed:
Digestion of native collagen in the triple helical region at -|-Gly bonds. With synthetic peptides, a preference is shown for Gly at P3 and P1', Pro and Ala at P2 and P2', and hydroxyproline, Ala or Arg at P3'.
Systematic name:
-
Alternative Name(s):
  • Achromobacter iophagus collagenase
  • Aspergillopeptidase C
  • Azocollase
  • Clostridiopeptidase A
  • Clostridiopeptidase I
  • Clostridiopeptidase II
  • Clostridium histolyticum collagenase
  • Clostridium histolyticum proteinase A
  • Collagen peptidase
  • Collagen protease
  • Collagenase
  • Collagenase A
  • Collagenase I
  • Collagenase MMP-1
  • Interstitial collagenase
  • Kollaza
  • MMP-1
  • MMP-8
  • Matirx metalloproteinase-18
  • Matrix metalloproteinase-1
  • Matrix metalloproteinase-8
  • Metallocollagenase
  • Metalloproteinase-1
  • Nucleolysin
  • Soycollagestin

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF18496
Domain description: Collagenase G catalytic helper subdomain
Occurring in:
  1. Collagenase ColG
The deposited structure of PDB entry 7z5u contains 1 copy of Pfam domain PF18496 (Collagenase G catalytic helper subdomain) in Collagenase ColG. Showing 1 copy in chain A.

PF01752
Domain description: Collagenase
Occurring in:
  1. Collagenase ColG
The deposited structure of PDB entry 7z5u contains 1 copy of Pfam domain PF01752 (Collagenase) in Collagenase ColG. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002169
Domain description: Peptidase M9A/M9B, collagenase, bacterial
Occurring in:
  1. Collagenase ColG
IPR013320
Domain description: Concanavalin A-like lectin/glucanase domain superfamily
Occurring in:
  1. Collagenase ColG
IPR041379
Domain description: Collagenase ColG-like, catalytic helper subdomain
Occurring in:
  1. Collagenase ColG