Function and Biology Details
Reactions catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-158745 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Cullin-7
Molecule details ›
Chain: C
Length: 1700 amino acids
Theoretical weight: 191.56 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 1700 amino acids
Theoretical weight: 191.56 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
Q14999 (Residues: 1-1698; Coverage: 100%)
Sequence domains:
F-box/WD repeat-containing protein 8
Molecule details ›
Chain: F
Length: 600 amino acids
Theoretical weight: 67.63 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: F-box domain
Length: 600 amino acids
Theoretical weight: 67.63 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q8N3Y1 (Residues: 1-598; Coverage: 100%)
Sequence domains: F-box domain
E3 ubiquitin-protein ligase RBX1
Molecule details ›
Chain: R
Length: 108 amino acids
Theoretical weight: 12.29 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: RING-H2 zinc finger domain
Length: 108 amino acids
Theoretical weight: 12.29 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P62877 (Residues: 1-108; Coverage: 100%)
Sequence domains: RING-H2 zinc finger domain
S-phase kinase-associated protein 1
Molecule details ›
