› 7z9y

X-ray diffraction
1.04Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130112 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 4 Chain: AAA
Molecule details ›
Chain: AAA
Length: 129 amino acids
Theoretical weight: 15.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O60885 (Residues: 44-168; Coverage: 9%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain

Ligands and Environments

2 bound ligands:
Ligand GOL 3 x GOL
Ligand PYZ 2 x PYZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P212121
Unit cell:
a: 37.967Å b: 43.113Å c: 79.374Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.192 0.208
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 citations in other articles

Fragment expansion with NUDELs - poised DNA-encoded libraries.
Salvini et al. (2023)

1 mention without citation

Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions.
Davison et al. (2022)