› 7zch

Electron Microscopy
3.6Å resolution

CHMP2A-CHMP3 heterodimer (410 Angstrom diameter)

Released:
DOI: 10.2210/pdb7zch/pdb
PDB entry 7zch coloured by chain, front view.
PDB entry 7zch coloured by chain, side view.
PDB entry 7zch coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of CHMP2A-CHMP3 ESCRT-III polymer assembly and membrane cleavage.
Azad K, Guilligay D, Boscheron C, Maity S, De Franceschi N, Sulbaran G, Effantin G, Wang H, Kleman JP, Bassereau P, Schoehn G, Roos WH, Desfosses A, Weissenhorn W
Nat Struct Mol Biol (2023)
PMID: 36604498
Related structures: EMD-14631

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-271720 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Charged multivesicular body protein 2a Chain: B
Molecule details ›
Chain: B
Length: 147 amino acids
Theoretical weight: 17.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O43633 (Residues: 8-154; Coverage: 66%)
Gene names: BC2, CHMP2, CHMP2A
Sequence domains: Snf7
Charged multivesicular body protein 3 Chain: A
Molecule details ›
Chain: A
Length: 159 amino acids
Theoretical weight: 18.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y3E7 (Residues: 11-169; Coverage: 72%)
Gene names: CGI-149, CGI149, CHMP3, NEDF, VPS24
Sequence domains: Snf7

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-14631
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Roles of ESCRT-III polymers in cell division across the tree of life.
Carlton et al. (2023)
10 other articles