› 7zdz

Electron Microscopy
4.3Å resolution

Cryo-EM structure of the human inward-rectifier potassium 2.1 channel (Kir2.1)

Released:
DOI: 10.2210/pdb7zdz/pdb
PDB entry 7zdz coloured by chain, front view.
PDB entry 7zdz coloured by chain, side view.
PDB entry 7zdz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-electron microscopy unveils unique structural features of the human Kir2.1 channel.
Fernandes CAH, Zuniga D, Fagnen C, Kugler V, Scala R, Péhau-Arnaudet G, Wagner R, Perahia D, Bendahhou S, Vénien-Bryan C
OpenAccess logo Sci Adv 8 eabq8489 (2022)
PMID: 36149965
Related structures: EMD-14678

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159065 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inward rectifier potassium channel 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 427 amino acids
Theoretical weight: 48.34 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P63252 (Residues: 1-427; Coverage: 100%)
Gene names: IRK1, KCNJ2
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand K 1 x K
Ligand SR 2 x SR
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.3Å
Relevant EMDB volumes: EMD-14678
Expression system: Komagataella pastoris

Quick links

Citations

3 citation in other articles

Chronic Propafenone Application Increases Functional KIR2.1 Expression In Vitro.
Li et al. (2023)
2 more

2 mentions without citation

Cryo-electron microscopy unveils unique structural features of the human Kir2.1 channel.
Fernandes et al. (2022)
1 more