› 7zg3

X-ray diffraction
2.3Å resolution

Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH011228

Released:
DOI: 10.2210/pdb7zg3/pdb
PDB entry 7zg3 coloured by chain, front view.
PDB entry 7zg3 coloured by chain, side view.
PDB entry 7zg3 coloured by chain, top view.
Source organism: Mus musculus
Entry authors: Davies JR, Scaletti E, Stenmark P

Function and Biology Details

Reaction catalysed: 
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126665 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
N-glycosylase/DNA lyase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 318 amino acids
Theoretical weight: 35.82 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: O08760 (Residues: 9-325; Coverage: 92%)
Gene name: Ogg1
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand IUX 3 x IUX
Ligand NI 1 x NI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P212121
Unit cell:
a: 80.79Å b: 81.318Å c: 169.905Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.277 0.276 0.307
Expression system: Escherichia coli

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