› 7zh7

Electron Microscopy
3.3Å resolution

Cryo-EM structure of ex vivo AA amyloid from renal tissue of a short hair cat deceased in a shelter

Released:
DOI: 10.2210/pdb7zh7/pdb
PDB entry 7zh7 coloured by chain, front view.
PDB entry 7zh7 coloured by chain, side view.
PDB entry 7zh7 coloured by chain, top view.
Source organism: Felis catus
Primary publication:
Cryo-EM structure of ex vivo fibrils associated with extreme AA amyloidosis prevalence in a cat shelter.
Schulte T, Chaves-Sanjuan A, Mazzini G, Speranzini V, Lavatelli F, Ferri F, Palizzotto C, Mazza M, Milani P, Nuvolone M, Vogt AC, Vogel M, Palladini G, Merlini G, Bolognesi M, Ferro S, Zini E, Ricagno S
Nat Commun 13 7041 (2022)
PMID: 36396658
Related structures: EMD-14726

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173064 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serum amyloid A protein Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 129 amino acids
Theoretical weight: 14.45 KDa
Source organism: Felis catus
UniProt:
  • Canonical: Q1T770 (Residues: 1-129; Coverage: 100%)
Gene name: SAA
Sequence domains: Serum amyloid A protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-14726

Quick links

Citations

3 citation in other articles

AA-amyloidosis in cats (Felis catus) housed in shelters.
Ferri et al. (2023)
2 more

1 mention without citation

Cryo-EM structure of ex vivo fibrils associated with extreme AA amyloidosis prevalence in a cat shelter.
Schulte et al. (2022)