› 7zha

Electron Microscopy
3.55Å resolution

Structure of human OCT3 in complex with inhibitor decynium-22

Released:
DOI: 10.2210/pdb7zha/pdb
PDB entry 7zha coloured by chain, front view.
PDB entry 7zha coloured by chain, side view.
PDB entry 7zha coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of organic cation transporter-3 inhibition.
Khanppnavar B, Maier J, Herborg F, Gradisch R, Lazzarin E, Luethi D, Yang JW, Qi C, Holy M, Jäntsch K, Kudlacek O, Schicker K, Werge T, Gether U, Stockner T, Korkhov VM, Sitte HH
OpenAccess logo Nat Commun 13 6714 (2022)
PMID: 36344565
Related structures: EMD-14728

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131113 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Solute carrier family 22 member 3 Chain: A
Molecule details ›
Chain: A
Length: 556 amino acids
Theoretical weight: 61.33 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O75751 (Residues: 1-556; Coverage: 100%)
Gene names: EMTH, OCT3, SLC22A3
Sequence domains: Major Facilitator Superfamily

Ligands and Environments

1 bound ligand:
Ligand JDW 1 x JDW
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.55Å
Relevant EMDB volumes: EMD-14728
Expression system: Homo sapiens

Quick links

Citations

5 review citations

Membrane transporters in drug development and as determinants of precision medicine.
Galetin et al. (2024)
4 more

2 mentions without citation

Atomistic description of the OCTN1 recognition mechanism via in silico methods.
Ben Mariem et al. (2024)
1 more