› 7zi0

X-ray diffraction
3Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142137 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein smoothened; Soluble cytochrome b562 Chains: A, B
Molecule details ›
Chains: A, B
Length: 638 amino acids
Theoretical weight: 70.78 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: Q99835 (Residues: 32-428, 443-555; Coverage: 67%)
  • Canonical: P0ABE7 (Residues: 23-127; Coverage: 99%)
Gene names: SMO, SMOH, cybC
Sequence domains:

Ligands and Environments

5 bound ligands:
Ligand V0S 2 x V0S
Ligand CLR 2 x CLR
Ligand NAG 1 x NAG
Ligand NA 2 x NA
Ligand MPG 1 x MPG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: C2
Unit cell:
a: 122.86Å b: 63.15Å c: 208.06Å
α: 90° β: 96.29° γ: 90°
R-values:
R R work R free
0.233 0.231 0.275
Expression system: Homo sapiens

Quick links

Citations

4 review citations

Unraveling a mystery: Why human cells require cholesterol.
Yeagle PL. (2022)
3 more