› 7zi8

X-ray diffraction
1.99Å resolution

Function and Biology Details

Reactions catalysed: 
ATP + deoxyguanosine = ADP + dGMP
NTP + deoxycytidine = NDP + dCMP
ATP + deoxyadenosine = ADP + dAMP
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-541552 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Deoxycytidine kinase Chain: A
Molecule details ›
Chain: A
Length: 280 amino acids
Theoretical weight: 32.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P27707 (Residues: 1-260; Coverage: 100%)
Gene name: DCK
Sequence domains: Deoxynucleoside kinase

Ligands and Environments

3 bound ligands:
Ligand UDP 1 x UDP
Ligand J5U 1 x J5U
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 2
Spacegroup: P4122
Unit cell:
a: 68.618Å b: 68.618Å c: 121.247Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.201 0.263
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Therapies from Thiopeptides.
Hwang et al. (2023)

1 mention without citation

From a drug repositioning to a structure-based drug design approach to tackle acute lymphoblastic leukemia.
Saez-Ayala et al. (2023)