› 7zj8

Electron Microscopy
3.1Å resolution

X-31 Hemagglutinin Precursor HA0 at pH 7.5 after reneutralization

Released:
DOI: 10.2210/pdb7zj8/pdb
PDB entry 7zj8 coloured by chain, front view.
PDB entry 7zj8 coloured by chain, side view.
PDB entry 7zj8 coloured by chain, top view.
Source organisms:
Primary publication:
Reversible structural changes in the influenza hemagglutinin precursor at membrane fusion pH.
Garcia-Moro E, Zhang J, Calder LJ, Brown NR, Gamblin SJ, Skehel JJ, Rosenthal PB
OpenAccess logo Proc Natl Acad Sci U S A 119 e2208011119 (2022)
PMID: 35939703
Related structures: EMD-14744

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137020 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (5 distinct):
Fibritin; Hemagglutinin Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 554 amino acids
Theoretical weight: 62.03 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P03437 (Residues: 17-520, 549-549; Coverage: 92%)
  • Canonical: P10104 (Residues: 459-484; Coverage: 5%)
Gene names: HA, wac
Sequence domains: Haemagglutinin

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
2 bound ligands:
Ligand NAG 6 x NAG
Ligand BOG 3 x BOG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-14744
Expression system: Homo sapiens

Quick links

Citations

4 citation in other articles

Intradermal Immunization of Soluble Influenza HA Derived from a Lethal Virus Induces High Magnitude and Breadth of Antibody Responses and Provides Complete Protection In Vivo.
Raj et al. (2023)
3 more