› 7zjg

Electron Microscopy
3.49Å resolution

Probenecid

Released:
DOI: 10.2210/pdb7zjg/pdb
PDB entry 7zjg coloured by chain, front view.
PDB entry 7zjg coloured by chain, side view.
PDB entry 7zjg coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function.
Zhang L, Simonsen C, Zimova L, Wang K, Moparthi L, Gaudet R, Ekoff M, Nilsson G, Hellmich UA, Vlachova V, Gourdon P, Zygmunt PM
OpenAccess logo Nat Commun 13 7483 (2022)
PMID: 36470868
Related structures: EMD-14747

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194387 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1026 amino acids
Theoretical weight: 116.43 KDa
Source organism: Rattus norvegicus
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q9WUD2 (Residues: 1-761; Coverage: 100%)
Gene names: Sac2b, Trpv2, Vrl1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.49Å
Relevant EMDB volumes: EMD-14747
Expression system: Saccharomyces cerevisiae

Quick links

Citations

2 review citations

TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases.
Zhang et al. (2023)
1 more