EC 7.6.2.2: ABC-type xenobiotic transporter
Reaction catalysed:
ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2)
Systematic name:
ATP phosphohydrolase (ABC-type, xenobiotic-exporting)
Alternative Name(s):
- ATP phosphohydrolase (steroid-exporting)
- MDR protein
- Multidrug-resistance protein
- P-glycoprotein
- PDR protein
- Pleiotropic-drug-resistance protein
- Steroid-transporting ATPase
- Xenobiotic-transporting ATPase
EC 7.6.2.1: P-type phospholipid transporter
Reaction catalysed:
ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)
Systematic name:
ATP phosphohydrolase (P-type, phospholipid-flipping)
Alternative Name(s):
- Aminophospholipid-transporting ATPase
- Flippase
- Phospholipid-transporting ATPase
GO terms
Biochemical function:
- ABC-type transporter activity
- floppase activity
- ATPase-coupled intramembrane lipid transporter activity
- ceramide floppase activity
- phosphatidylethanolamine flippase activity
- phosphatidylcholine floppase activity
- xenobiotic transmembrane transporter activity
- ATPase-coupled transmembrane transporter activity
- transmembrane transporter activity
- ATP hydrolysis activity
- efflux transmembrane transporter activity
- ABC-type xenobiotic transporter activity
- ATP binding
Biological process:
- positive regulation of response to drug
- establishment of blood-retinal barrier
- xenobiotic transport across blood-brain barrier
- xenobiotic detoxification by transmembrane export across the plasma membrane
- response to cyclosporin A
- response to quercetin
- response to codeine
- cellular response to L-glutamate
- cellular response to borneol
- regulation of intestinal absorption
- positive regulation of establishment of Sertoli cell barrier
- cellular response to nonylphenol
- negative regulation of sensory perception of pain
- response to glycoside
- protein localization to bicellular tight junction
- response to L-glutamate
- export across plasma membrane
- ceramide translocation
- response to antineoplastic agent
- response to alcohol
- response to thyroxine
- cellular response to dexamethasone stimulus
- response to dexamethasone
- cellular hyperosmotic salinity response
- cellular response to estradiol stimulus
- cellular response to tumor necrosis factor
- cellular response to alkaloid
- cellular response to antibiotic
- cellular response to lipopolysaccharide
- cellular response to external biotic stimulus
- establishment of blood-brain barrier
- transmembrane transport
- intestinal absorption
- terpenoid transport
- response to cadmium ion
- phospholipid translocation
- daunorubicin transport
- cellular response to mycotoxin
- maintenance of blood-brain barrier
- response to glucagon
- response to vitamin D
- response to vitamin A
- response to progesterone
- response to lipopolysaccharide
- response to estradiol
- response to nutrient levels
- response to organic cyclic compound
- response to mycotoxin
- hormone transport
- response to xenobiotic stimulus
- circadian rhythm
- lactation
- female pregnancy
- placenta development
- response to hypoxia
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotations
IPR036640
Domain description:
ABC transporter type 1, transmembrane domain superfamily
Occurring in:
Occurring in: